Highlights:

  • CanSinoBIO Biologics Inc’s single-dose COVID-19 vaccine, tested at a lower dosage than that for adults, is safe and triggers an immune response in children
  • Researchers planned to lower the dosage after a few participants developed fever and headaches graded at level 2 severity-the second-lowest of four levels
  • The trial engaged around 150 children and nearly 300 adults

CanSinoBIO Biologics Inc’s (CanSinoBIO) single-dose COVID-19 vaccine, tested at a lower dosage safer for children than that for adults, is safe and triggers an immune response in children aged 6-17, results from a small trial exhibited.

Researchers planned to lower the dosage after a few participants developed fever and headaches graded at level 2 severity which is the second-lowest of four levels. In children, the lower dose triggered higher antibody levels compared to the dosages approved for use in adults in China, as per peer-reviewed finding supplementary data from an intermediate stage level.

The trial engaged around 150 children and nearly 300 adults. The result further asserted that the children administered one lower dose had a stronger antibody response than the adults who received a booster shot 56 days after the first dose.

However, the antibody reading did not display to what extent the vaccine can provide protection against COVID -19, researchers from the Chinese disease control agency, CanSinoBIO, and other Chinese institutes warned in a statement.

CanSinoBIO’s vaccines have not yet received a go-ahead for children. China has approved two vaccines, developed by Sinovac and Sinopharm, for use in children from the age of three. However, the vaccinations are yet to commence for those under 12.

The statement added that the booster shot for CanSinoBIO’s vaccine improved antibody response in participants from different age groups, notably for older adults. Nevertheless, cellular responses, which is another important part of the human immune system, were not boosted by a second shot and the researchers suggested a wider interval than 56 days should be considered.

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